Nirmatrelvir/Ritonavir Pfizer

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Nirmatrelvir/Ritonavir Pfizer is taken orally, twice daily for 5 days1Treatment should begin as soon as possible following a positive test and ≤5 days of symptom onset.​​​​​​​​​​​​​​Nirmatrelvir/Ritonavir Pfizer recommended dosage for 5 consecutive days1 Morning Dose
  • Two pink 150-mg tablets of nirmatrelvir
  • One white 100-mg tablet of ritonavir

Patients should take all 3 tablets together.

Evening Dose
  • Two pink 150-mg tablets of nirmatrelvir
  • One white 100-mg tablet of ritonavir

Patients should take all 3 tablets together.

Nirmatrelvir/Ritonavir Pfizer dosing instructions1
  • Nirmatrelvir/Ritonavir Pfizer can be taken with or without food
  • The tablets should be swallowed whole and not chewed, broken, or crushed
  • If a dose of Nirmatrelvir/Ritonavir Pfizer is missed within 8 hours of the time it is usually taken, the patient should take it as soon as possible and resume the normal dosing schedule. If the patient misses a dose by more than 8 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. The patient should not double the dose to make up for a missed dose
  • If a patient requires hospitalization due to severe or critical COVID-19 after starting treatment with Nirmatrelvir/Ritonavir Pfizer, the patient should complete the full 5-day treatment course at the discretion of his/her healthcare provider.
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Reference: 1. Nirmatrelvir/ ritonavir Pfizer Summary of Product Characteristics. 
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